个人信息
姓名：林红艳
学历：理学博士
职称：讲师
E-mail：hylin@mail.ccnu.edu.cn
教育与研究经历
学术兼职
Journal of Agricultural and Food Chemistry期刊顾问编辑
研究领域与兴趣
1.农药化学生物学
2.结构生物学
3.基于靶标结构的新型药物分子的合理设计
承担项目与课题信息
1.国家自然科学基金青年基金，主持，在研。
2.湖北省自然科学基金青年项目，主持，在研。
3.中央高校专项基金新进教师，中央高校基本科研业务费，新进教师科研启动专项，主持，在研。
学术成果（代表性论文）
【1】Hong-Yan Lin, Xi Chen, Jia-Nan Chen, Da-Wei Wang, Feng-Xu Wu, Song-Yun Lin, Chang-Guo Zhan, Jia-Wei Wu, Wen-Chao Yang*, Guang-Fu Yang*. Crystal Structure of 4-Hydroxyphenylpyruvate Dioxygenase in Complex with Substrate Reveals a New Starting Point for Herbicide Discovery. Research. 2019, 2602414.
【2】Hong-Yan Lin, Jing-Fang Yang, Da-Wei Wang, Ge-Fei Hao, Jiang-Qing Dong, Yu-Xia Wang, Wen-Chao Yang,* Jia-Wei Wu, Chang-Guo Zhan, Guang-Fu Yang*. Molecular insights into the mechanism of 4-hydroxyphenylpyruvate dioxygenase inhibition: enzyme kinetics, X-ray crystallography and computational simulations. FEBS J. 2019, 286, 975–990.
【3】Bo He, Feng-Xu Wu, Liang-Kun Yu, Lei Wu, Qiong Chen, Ge-Fei Hao, Wen-Chao Yang, Hong-Yan Lin,* Guang-Fu Yang* Discovery of Novel Pyrazole−Quinazoline-2,4-dione Hybrids as 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors. J. Agric. Food Chem. 2020, 68, 5059-5067.
【4】Ren-Yu Qu, Jia-Xu Nan, Yao-Chao Yan, Qiong Chen, Ferdinand Ndikuryayo, Xue-Fang Wei, Wen-Chao Yang, Hong-Yan Lin,* Guang-Fu Yang,* Structure-Guided Discovery of Silicon-Containing Subnanomolar Inhibitor of Hydroxyphenylpyruvate Dioxygenase as a Potential Herbicide. J. Agric. Food Chem. 2021, 69, 459-473.
【5】Xiao-Ning Wang‡, Hong-Yan Lin‡, Jun-Jun Liu, Xin-Yun Zhao, Xi Chen*, Wen-Chao Yang*, Guang-Fu Yang*, Chang-Guo Zhan. The structure of 4-hydroxylphenylpyruvate dioxygenase complexed with 4-hydroxylphenylpyruvic acid reveals an unexpected inhibition mechanism. Chinese Chem. Lett. 2021.
