Chinese Version (中文版)
Resume
Education
09/1988-06/1992 Central China NormalUniversity, B.S., Biology
09/2002-06/2004 Central China NormalUniversity, M.S., Developmental Biology
09/2004-06/2007 Wuhan University,Ph.D., Genetics
Work Experience
09/1992-12/2002 Wuhan Bacteriophage Factory, Researchscientist, China
03/2012-03/2013 WeillCornell Medical College, Cornell University,uUAS
07/2007-06/2009 CentralChina Normal University, Assistant Professor
07/2009-06/2016 Central China Normal University, AssociateProfessor
07/2016-present Central China Normal University,Professor
ResearchFields and Interests
1.Biochemistry and Molecular Biology,DNA-subclone, site-mutation,Enzyme design andmodification, Enzyme structure and function, Enzyme kinetics,Expression, purification and characterization ofproteins, Interaction between enzyme and ligands (subsrate, metal ion,inhibitor, et al.)
2. Environmental Biology and MicrobiologyBiodegradation of Pollutants inEnvionment
3. Drug design and screening (including medicine andpesticide)based on target structure-activity relationship
SelectedPublications：
1. LinglingFeng, Brandoch Cook, Su-YiTsai, Ting Zhou, Brooke LaFlamme, Todd Evans*, Shuibing Chen*. Discovery of a Small-Molecule BMP Sensitizer for Human Embryonic Stem Cell Differentiation. Cell Reports, 2016, 15, 2063-2075
2. Haifeng He, Wei Wang, Yuan Zhou, Qin Xia, Yanliang Ren, Jiangtao Feng,Hao Peng, Hongwu He*, Lingling Feng*Rationaldesign, synthesis and biological evaluation of 1,3,4-oxadiazole pyrimidine derivatives as novel pyruvate dehydrogenase complex E1 inhibitors. Bioorganic& Medicinal Chemistry. 2016, 24, 1879-1888.
3. Haifeng He, Jiangtao Feng, Junbo He, Qin Xia, Yanliang Ren, Fang Wang,Hao Peng, Hongwu He* andLingling Feng*Design, synthesis, biological evaluation and molecular docking of amide and sulfamide derivatives as Escherichia coli pyruvate dehydrogenase complex E1inhibitors. RSC Adv., 2016, 6, 4310-4320
4.LinglingFeng, Junbo He, Haifeng He, Lulu Zhao, LingfuDeng, Li Zhang, Lin Zhang, Yanliang Ren, Jian Wan*, and Hongwu He*.The design, synthesis and biological evaluationof novel thiamin diphosphate analog inhibitors against pyruvate dehydrogenase multienzyme complex E1 from Escherichia coli. Org. Biomol. Chem., 2014, 12(44), 8911-8918.
5.Lingling Feng,Yao Sun, Hui Deng, Ding Li, Jian Wan, Xiaofeng Wang,Weiwei Wang, Xun Liao, Yanliang Ren, Jian Wan*and Xiaopeng Hu*. Structural and biochemical characterization of fructose-1,6/sedoheptulose-1,7-bisphosphatase from the cyanobacterium Synechocystis strain 6803. FEBS J. 2014, 281(3), 916-926.
6. YaoSun, Rui Zhang, Ding Li,Lingling Feng*,Di Wu, Lina Feng, Peipei Huang, Yanliang Ren, JiangTao Feng, San Xiao, JianWan*. Pharmacophore-based virtual screening and experimental validation ofnovel inhibitors against cyanobacterial fructose-1, 6-/sedoheptulose-1, 7-bisphosphatase. J. Chem. Inf. Model. 2014, 54 (3), 894-901.
7. Qi-Dong Tu, Ding Li,Yao Sun, Xin-Ya Han, Fan Yi, Yibamu Sha, Yan-Liang Ren, Ming-Wu Ding,Ling-Ling Feng*, Jian Wan*.Design and syntheses of novelN0-((4-oxo-4H-chromen-3-yl) methylene)benzohydrazide as inhibitors ofcyanobacterial fructose-1,6-/sedoheptulose- 1,7- bisphosphatase. Bioorg. Med. Chem. 2013, 21, 2826-2831
8. Yao Sun, Xun Liao, Ding Li,LinglingFeng *,Xiaofeng Wang, Jing Jin, FanYi, Li Zhou, JianWan*. Study on the interaction betweencyanobacteria FBP/SBPase and metal ions. Spectrochim. Acta A. 2012, 89,337-344
9．Lingling Feng*, Li Zhou, Yao Sun, Jie Gui, Xiaofeng Wang, Ping Wu, Jian Wan*, Yanliang Ren,Shengxiang Qiu, Xiaoyi Wei, Jun Li.Specific inhibitions of annonaceousacetogenins on class II 3-hydroxy-3-methylglutaryl coenzyme A reductase fromStreptococcus pneumoniae. Bioorg. Med. Chem. 2011, 19, 3512 – 3519
10. Pengna Li, Lizhi Zhang*, WeiweiWang, Jiali Su,Lingling Feng*.Rapid catalytic microwave method to damage microcystis aeruginosa with FeCl3-loaded active carbon. Environ. Sci. Technol. 2011, 45, 4521 – 4526.
Research Grants
2015.1-2018.12 Study on the active sites and catalyzedmolecular mechanism of microcystinase A (NSFC Grant 21472061, principal investigator)
2013.1-2016.12 Study on catalyzed molecule mechanism of aflatoxin-detoxizyme and its orientation rebuilt (NSFC Grant 21272089, principal investigator )
2011.1-2013.12 The research on the mechanism between the active center of FBP/SBPase and the ligands as well as the design and screening of the lead constructs of its inhibitors(NSFC Grant 21072073, principal investigator)
2009.1-2011.12 Study on the interaction between SBPase and substrate along with design and screening of its inhibitors (NSFC Grant 20872044, principal investigator)
2009.1-2011.12 Study on the interaction between streptococcus pneumoniae 3-hydroxy-3-methylglutary coenzyme A reductaseand ligands along with design and screening of its potential inhibitors(NSFC Grant 20873049, co-investigator)
2007.1-2008.12 Molecular Mechanisms for Bio-rational Design of Photosynthesis System- Targeted Herbicides (NSFC Grant2007CB116302, co-investigator)
